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ALWAYS check with your vet before administering any medication to your pet. Your pet may have underlying health issues and side effects and drug interactions must be considered. This page is for reference only.
Pepcid A/C (famotadine): Dr. Katherine Tolbert, DVM, DACVIM who is a Winn funded researcher, from the University of TN states that “in regards to Pepcid, it can be given with food. That does not affect its efficacy, unlike Prilosec which needs to be given 30 minutes before a meal. This info is over Pepcid and its effect on changes of stomach acidity and some drugs: There are some drugs that are absorbed better in the presence of stomach acid (example: itraconazole, ketoconazole, fluconazole). These drugs should be given at least an hour apart from famotidine. Cefpodoxime does not absorb as well in the presence of famotidine. This effect is reduced by giving both medications with food. Oral iron supplements do not absorb into the body as well in the presence of famotidine. Stagger their administration by at least an hour. That’s a difficult question to answer. It is fine to co-administer at the same with most drugs. However, some drugs can be affected by a change in gastric pH. Some examples of drugs that it could affect include other acid suppressants such as Prilosec, oral iron, sucralfate, etc. So you would want to space it out by 1-2 hours between administration of those types of drugs. Generally speaking, drugs such as antibiotics, NSAIDs, appetite stimulants, anti-emetics, steroids are not affected by the co-administration of Pepcid.”
3. Tolbert K, Bissett S, King A, et al. Efficacy of oral famotidine and 2 omeprazole formulations for the control of intragastric pH in dogs. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2011;25:47-54.
4. Sutalo S, Ruetten M, Hartnack S, et al. The Effect of Orally Administered Ranitidine and Once-Daily or Twice-Daily Orally Administered Omeprazole on Intragastric pH in Cats. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2015;29:840-846. https://www.ncbi.nlm.nih.gov/pubmed/25966746
5. Parkinson S, Tolbert K, Messenger K, et al. Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2014. https://www.ncbi.nlm.nih.gov/pubmed/25537303
8. Jung SB, Nagaraja V, Kapur A, et al. Association between vitamin B12 deficiency and long-term use of acid-lowering agents: a systematic review and meta-analysis. Internal medicine journal 2015;45:409-416. https://www.ncbi.nlm.nih.gov/pubmed/25583062
13. Komazawa Y, Adachi K, Mihara T, et al. Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection. Journal of gastroenterology and hepatology 2003;18:678-682. https://www.ncbi.nlm.nih.gov/pubmed/12753150
14. Miner PB, Jr., Allgood LD, Grender JM. Comparison of gastric pH with omeprazole magnesium 20.6 mg (Prilosec OTC) o.m. famotidine 10 mg (Pepcid AC) b.d. and famotidine 20 mg b.d. over 14 days of treatment. Alimentary pharmacology & therapeutics 2007;25:103-109. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03129.x/full
17. Lane M, Larson J, Hecht S, et al. Medical management of gastrinoma in a cat. JFMS Open Reports 2016;2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362883/
A lot of the published work is in dogs but it is used and studied at the veterinary colleges in cats. More work looks at omeprazole being it is a more effective antacid in cats.